Neuromodulatory Induction of Meditative States

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January 2020

Received funding for project.

November 2022

Began running participants.

72

Expected total number of participants.

Study Status

Protocol Design

100%

Data Collection

100%

Data Analysis

90%

Manuscript(s) Preparation

90%

Publication

90%

Protocol 003

Neuromodulatory Induction of Meditative States For Experienced Meditators

If you volunteer to participate in this study, your first session (Day 1) will include receiving a magnetic resonance imaging (MRI) structural image of your brain on the first floor of our building and then come up to our suite on the 5th floor to complete a series of questionnaires and become familiar with the experimental design.

For sessions two, three, four, and five (Day 2 through Day 5), you will be meditating and receiving ultrasound stimulation (for a total of 5 site visits).

Protocol 003b

Towards Enhancing Meditation with Focused Ultrasound Neuromodulation in Novice Meditators

If you volunteer to participate in this study, we will first ask you to complete four remotely guided meditation sessions: Two 1.5-hour sessions (proctored over Zoom) and two 45-minute sessions (proctored) to introduce you to Vipassana meditation techniques.

For your first on-site visit, we will ask you to get a magnetic resonance imaging (MRI) structural image of your brain on the first floor of our building and then come up to our suite on the fifth floor to complete a series of questionnaires and become familiar with the experimental design.

After your MRI visit, there will be four days where you will be receiving ultrasound stimulation (for a total of 5 site visits).

Proceedings

Project Contributors

2024

Cain, J, Brandmeyer, T., Sanguinetti, J., Simonian, N., Reggente, N. (2024) Facilitating Meditation with Focused Ultrasound Neuromodulation: A First Investigation in Experienced Practitioners. OSF Preprint.

2025

Jinich-Diamant, A., Simpson, S., Zuniga-Hertz, J. P., Chitteti, R., Schilling, J. M., Bonds, J. A., … & Patel, H. H. (2025). Neural and molecular changes during a mind-body reconceptualization, meditation, and open-label placebo healing intervention. Communications Biology, 8(1), 1525.

2024

Gorka, S. M., Jimmy, J., Koning, K., Phan, K. L., Rotstein, N., Hoang-Dang, B., Halavi, S., Spivak, N., Monti, M. M., Reggente, N., Bookheimer, S. Y., & Kuhn, T. P. (2024). Alterations in large-scale resting-state network nodes following transcranial focused ultrasound of deep brain structures. Frontiers in Human Neuroscience, 18.
Cain, J, Brandmeyer, T., Sanguinetti, J., Simonian, N., Reggente, N. (2024) Facilitating Meditation with Focused Ultrasound Neuromodulation: A First Investigation in Experienced Practitioners.
Cain, J., Simonian, N., Reggente, N. (2024) Effective Deepening of Meditative-States with Focused Ultrasound Stimulation and its Moderation by Prior-Experience. OSF Preprint.
Ganesan, S., Tsuchiyagaito, A., Siegle, G. J., Goldin, P. R., Eyler, L. T., Treves, I., . . . King, A. P. (2024). ENIGMA-Meditation: Worldwide consortium for neuroscientific investigations of meditation practices. OSF Preprint.

2022

Kuhn, T., Indahlastari, A., Vila‐Rodriguez, F., Fonzo, G. A., Petersen, N., Rotstein, N. M., . . . Thompson, P. M. (2024). The ENIGMA Neuromodulation Working Group: Goals, Challenges, and Opportunities for the Field. OSF Preprint.
Dell’Italia, J., Sanguinetti, J. L., Monti, M. M., Bystritsky, A., & Reggente, N. (2022). Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation. Frontiers in Human Neuroscience, 16. [PDF]

2024

Cain, J.C., Simonian, N., Bystritsky, A., May, J., Reggente, N. (June 2024) Facilitating Meditation with Focused Ultrasound Neuromodulation: A First Investigation in Experienced Practitioners. Organization for Human Brain Mapping, South Korea. [Poster]
Cain,J., Simonian, N., Bystritsky, A., May, J., Reggente, N. (2024). Effective Deepening of Meditative States with Focused Ultrasound Stimulation and its Moderation by Prior Experience. Organization for Human Brain Mapping 2024, South Korea. [Poster]
Cain, J., Simonian, N., Bystritsky, A., May, J., & Reggente, N. (2024). Inducing Meditation with Ultrasound Brain Stimulation. Association for the Scientific Studies of Consciousness 2024, Tokyo, Japan. [Poster]

2023

Cain, J., Brandmeyer, T., Simonian, N., Sanguinetti, J., Young, S., Sacchet, M., Reggente, N. (2023, October 5-6) Facilitating Meditation with Focused Ultrasound Neuromodulation: A First Investigation in Experienced Practitioners. Mindfulness Mechanisms & Methods Meeting, St. Louis, Missouri, USA. [Poster]
Cain, J., Wang, G., Brandmeyer, T., Simonian, Sanguinetti, J., Young, S., Sacchet, M., N., Reggente, N. (2023, June 22-25). Towards Enhancing Meditation with Focused Ultrasound Neuromodulation in Expert Meditators. ASSC, New York, New York, USA. [Poster]
Cain, J., Brandmeyer, T., Simonian, N., Reggente, N. (2023, March 25-28). Towards Enhancing Meditation with Focused Ultrasound Neuromodulation in Expert Meditators. CNS, San Francisco, CA, USA. [Poster]

2023

Cain, J., Brandmeyer, T., Simonian, N., Reggente, N. (2023, May 22-28). Towards Enhancing Meditation with Focused Ultrasound Neuromodulation in Expert Meditators. TSC, Taormina, Sicily, Italy.

2024