Category: Protocols

Decoding Depth of Meditation: EEG Insights from Expert Vipassana Practitioners

Manuscript, Proceedings, Protocol-002

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Reggente, N., Kothe, C., Brandmeyer, T., Hanada, G., Simonian, N., Mullen, S., & Mullen, T. (2024). Decoding Depth of Meditation: EEG Insights from Expert Vipassana Practitioners. Biological Psychiatry Global Open Science, 5(1), 100402. https://doi.org/10.1016/j.bpsgos.2024.100402

Reggente, Nicco, et al. “Decoding Depth of Meditation: EEG Insights from Expert Vipassana Practitioners.” Biological Psychiatry Global Open Science, vol. 5, no. 1, Oct. 2024, p. 100402, doi:10.1016/j.bpsgos.2024.100402.

@article{Reggente_Kothe_Brandmeyer_Hanada_Simonian_Mullen_Mullen_2024, title={Decoding Depth of Meditation: EEG Insights from Expert Vipassana Practitioners}, volume={5}, url={https://doi.org/10.1016/j.bpsgos.2024.100402}, DOI={10.1016/j.bpsgos.2024.100402}, number={1}, journal={Biological Psychiatry Global Open Science}, author={Reggente, Nicco and Kothe, Christian and Brandmeyer, Tracy and Hanada, Grant and Simonian, Ninette and Mullen, Sean and Mullen, Tim}, year={2024}, month=oct, pages={100402} }

Since it’s inception, the Institute for Advanced Consciousness Studies has been driven by a mission to create what we call a “Qualia Compass”—a tool that can collect “mental souvenirs” from hard-to-achieve states of consciousness. The purpose? To help individuals return to those states more easily and remain there longer through personalized, multivariate neurofeedback. This ambitious project seeks to, first, democratize access to profound meditative experiences that typically require years of dedicated practice.

Our recent research represents a significant step toward this goal, successfully decoding self-reported meditative depth using EEG data from expert Vipassana practitioners. Rather than simply distinguishing meditation from mind-wandering (as most previous research has done), we’ve tackled the more nuanced challenge of differentiating between various depths of meditation—a critical advancement for developing effective neurofeedback tools.

Beyond Binary Classifications

Traditional approaches to meditation research often suffer from what we might call the “soup versus salad problem.” The vast majority of neuroscientific investigations into meditation have focused on comparing meditation to mind-wandering—essentially contrasting two fundamentally different cognitive states, akin to comparing soup to salad. While this approach has yielded valuable insights, it falls short of our more ambitious goal: understanding the subtle gradations within meditative states themselves.

Our research adopts the perspective of a master chef who, rather than comparing soup to salad, focuses on discerning subtle variations within a single complex soup (variations A1 and A2). This approach acknowledges that to truly master the art of making exceptional soup—or in our case, to understand and facilitate profound meditation—we must develop a nuanced understanding of the elements that differentiate various iterations of the same fundamental state. By examining gradations within the meditative experience, we can identify the specific neural patterns that characterize progressively deeper states of meditation.

This focus on nuances within a singular state promises to deepen our understanding of meditation’s neural correlates. Yet pursuing this approach introduces a methodological challenge that French philosopher Auguste Comte identified: one cannot simultaneously observe oneself walking on the street from a balcony. In meditation research, this manifests as the “observer effect”—the act of reporting one’s meditative state inevitably disrupts that state. That is, the moment we try and observe the state we wish to measure is the same moment that it is no longer that state.

The Spontaneous Emergence Solution

To address this dilemma, we introduced “spontaneous emergence” as an experiential sampling method. Rather than interrupting meditation with systematic probes, participants naturally reported their meditative depth when they spontaneously emerged from deeper states. This approach yielded comparable decoding performance to traditional probing methods while preserving ecological validity—providing a less intrusive way to gather phenomenological data during meditation.

Our study involved 34 expert Vipassana practitioners who visited our lab on two separate occasions. Using source-localized EEG activity in the theta, alpha, and gamma frequency bands, we built machine learning models that could predict meditative depth in unseen sessions—essentially, we trained the models on data from one visit and tested them on the other.

Remarkable Results

Despite conventional EEG channel-level methods failing to show significant correlations with meditation depth, our multivariate machine learning approaches demonstrated remarkable accuracy in predicting participants’ self-reported depth ratings. This suggests that the neural dynamics of varying meditation depths are too complex and non-linear to be captured by traditional univariate analyses.

Our best models achieved performance levels comparable to those seen in established EEG-based brain-computer interfaces, with area under the curve (AUC) scores approaching 0.81 for distinguishing between low and high meditation depths. To put this in perspective, this means our algorithm could correctly classify 81 out of 100 different depth reportings in the high versus low domain. This level of accuracy is particularly impressive considering the subtle, internally-generated nature of meditative states, approaching the performance of well-established brain-computer interfaces used for detecting much more distinct phenomena like imagined hand movements.

For the continuous 0-5 scale, our models achieved a mean absolute error (MAE) as low as 1.15, substantially better than chance (1.51). Think of this as a meditation depth “thermometer” that’s typically just over one degree off—if a practitioner reports being at level 4, our algorithm might predict 3 or 5, but rarely would it mistake a shallow level 1 for a profound level 5 experience.

Perhaps most remarkably, the “spontaneous emergence” method—where participants naturally reported their depth when emerging from meditation—performed just as well as the more intrusive probing approach, while providing more ecological validity and yielding more data points.

The connectivity patterns we observed revealed fascinating neural signatures across frequency bands. In the theta band, we found increased frontal-midline activity—a known signature of focused-attention meditation—within a complex interplay of activations in right parietal and frontal pole regions. Alpha band activity showed distinct increases in midline parietal regions complemented by left parietal reduction, partially mapping onto trait-level mindfulness. Meanwhile, gamma band activity revealed increased occipitoparietal activity causally influencing midline parietal regions.

Ecological Validity and Phenomenological Coherence

Further analysis revealed that the spontaneous emergence method not only generated significantly more data points (45.6% higher reporting frequency) than the probe-based approach but also demonstrated stronger correlations with post-session assessments of meditation quality. Participants reported substantially higher confidence in their depth ratings when self-determining when to report (“emerge” condition) versus when prompted (“probe” condition). This enhanced metacognitive certainty was reflected in post-session questionnaire responses, where Toronto Mindfulness Scale (TMS) scores and Meditation Depth Index (MEDI) ratings showed stronger alignment with data collected during spontaneous emergence blocks. The phenomenological coherence between in-session spontaneous reports and post-session reflective assessments suggests that the emergence method captures more authentic aspects of the meditative experience—preserving the integrity of both the subjective experience and its neural correlates. This finding has profound implications for meditation research methodology, indicating that less intrusive approaches may yield more ecologically valid data while simultaneously improving participants’ ability to maintain deeper meditative states.

Next Steps: Personalized Neurofeedback

These findings represent a critical step toward developing more sophisticated, multivariate-based neurofeedback systems. By identifying the neural correlates representing different gradations of meditative depth, we can move beyond the limitations of traditional univariate neurofeedback protocols that risk misinterpreting certain states of consciousness as meditative.

Our ultimate goal is to use these personalized, real-time neural signatures to create adaptive neurofeedback systems that guide individuals toward deeper meditation states—serving as the “training wheels” that gradually become unnecessary as practitioners develop their own metacognitive skills for recognizing and maintaining profound meditative states.

By achieving a better understanding of Vipassana meditation, which underlies many modern mindfulness practices, this research stands to significantly advance the rapidly expanding realm of meditation-based interventions, potentially making these powerful practices more accessible and effective for a broader population.

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Virtual Reality vs. Reflective Chamber: New Study Shows Both Can Help Reduce Anxiety

Manuscript, Proceedings, Protocol-004

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Simonian, N., Johnson, M. A., Lynch, C., Wang, G., Kumaravel, V., Kuhn, T., Schoeller, F., & Reggente, N. (2025). Contrasting cognitive, behavioral, and physiological responses to breathwork vs. naturalistic stimuli in reflective chamber and VR headset environments. PLOS Mental Health., 2(3), e0000269. https://doi.org/10.1371/journal.pmen.0000269

Simonian, Ninette, et al. “Contrasting cognitive, behavioral, and physiological responses to breathwork vs. naturalistic stimuli in reflective chamber and VR headset environments.” PLOS Mental Health., vol. 2, no. 3, Mar. 2025, p. e0000269, doi:10.1371/journal.pmen.0000269.

@article{Simonian_Johnson_Lynch_Wang_Kumaravel_Kuhn_Schoeller_Reggente_2025, title={Contrasting cognitive, behavioral, and physiological responses to breathwork vs. naturalistic stimuli in reflective chamber and VR headset environments}, volume={2}, url={https://doi.org/10.1371/journal.pmen.0000269}, DOI={10.1371/journal.pmen.0000269}, number={3}, journal={PLOS Mental Health.}, author={Simonian, Ninette and Johnson, Micah Alan and Lynch, Caitlin and Wang, Geena and Kumaravel, Velu and Kuhn, Taylor and Schoeller, Félix and Reggente, Nicco}, year={2025}, month=mar, pages={e0000269} }

The newest study from the Institute for Advanced Consciousness Studies has found that anxiety-reducing experiences created in a novel “reflective chamber” environment called the MindGym can be successfully translated to more accessible virtual reality (VR) formats without losing their effectiveness. This finding opens up new possibilities for making anxiety management tools more widely available to those who need them.

The Challenge of Anxiety Management

With anxiety affecting nearly 20% of adults globally and existing treatments facing limitations like side effects and relapse potential, there’s an urgent need for innovative approaches. Traditional anxiety interventions, while beneficial, often face accessibility challenges – particularly in urban environments where access to natural settings for stress relief can be limited.

A Tale of Two Technologies

We compared two different approaches to delivering calming experiences: the MindGym, a chamber with reflective walls and programmable LED lighting, and an Oculus VR headset. We tested these platforms using two types of anxiety-reducing content: a guided breathwork exercise and naturalistic rain sounds. The study involved 126 participants, where we measured motion sickness, anxiety, valence, arousal, mindfulness, mood, cognitive performance, and physiological responses like heart rate and breathing patterns.

Screenshot of the rain stimuli

Results

Contrary to expectations, both the MindGym and VR platforms proved equally effective at reducing anxiety. This was particularly noteworthy because the VR experience was actually a recording of the MindGym environment rather than a fully interactive virtual space. The study found significant improvements across all conditions in:

– Cognitive performance

– Anxiety reduction

– Overall mood

– Breathing patterns (especially in the breathwork conditions)

Individual Differences Matter

Interestingly, the research revealed that personal characteristics played a significant role in how people responded to the interventions. People who scored higher on measures of “absorption” (the tendency to become deeply engaged in experiences) reported stronger feelings of awe and ego dissolution. Additionally, more open-minded individuals showed greater anxiety reduction during breathwork sessions compared to rain sound sessions.

What’s next? 

The study’s findings are exciting because they suggest that effective anxiety-reducing experiences can be created in specialized environments like the MindGym and then successfully adapted for more accessible VR platforms. This could lead to the development of widely available, standardized anxiety management tools that maintain their therapeutic effectiveness across different delivery systems.**

Current Limitations and Future Directions

While the immediate effects were promising, the benefits didn’t last long-term – follow-up measurements a week later showed anxiety levels had returned to baseline or higher. This suggests that regular practice or multiple sessions might be necessary for sustained benefits. Future research will focus on developing more complex, immersive experiences and investigating how these interventions might work for different types of anxiety.

The research represents an important step forward in making effective anxiety management tools more accessible to the general public, potentially bridging the gap between traditional therapies and the growing need for accessible mental health solutions. As we continue to face increasing mental health challenges globally, such technological innovations offer hope for more widely available and effective anxiety interventions.

The first author, N.S., is in the chamber.
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Can Aesthetic Chills Make Us More Generous? A Dictator Game Study

E4001, Musings

For one of our recent studies, we brought participants to the lab where they were presented with a series of auditory stimuli proven to cause chills in over 2/3 of the population while we recorded their neural and physiological data. Participants then completed tasks examining their post-intervention feelings, perspective-taking, and reactions to moral dilemmas, as well as ecologically valid tests of their non-strategic generosity (measured by costly sharing with real members of the LA community).

Prior to the study, all participants underwent an extensive battery of measures including:

These measures helped replicate prior findings in a single on-site study and assess both the independent effects of our intervention and the mediating effects of individual trait differences, which will help us better personalize future interventions and studies.

On the day of the study, participants were exposed to three chills-inducing stimuli that we have shown in over 7,000 diverse subjects across multiple countries to cause chills in approximately 75% of participants. Half of the participants additionally received a chills-augmenting intervention delivered by our patented frisson device strapped to their back, which delivers a cold stimulus along the spine timed to precise points where our previous studies showed chills were most likely to occur.

During the intervention, we recorded participants’ heart rate, skin conductance, and neural signals via scalp electrodes. While analysis of these signals is ongoing, our main hypothesis is that signal changes associated with psychedelic states of self-transcendence should be present in response to chills and should mediate the intervention’s transformative effects.

Post-intervention, participants reported their levels of self-transcendence and mood, were tested again on their maladaptive schemas, and engaged in two tasks designed to assess their actual helping decisions:

  1. Moral dilemmas task: Participants made difficult choices about moral situations where the welfare of the few was weighed against the welfare of many. Through process dissociation, we extracted two independent measures of moral decision-making: deontological inclination (the drive to avoid harm regardless of circumstances) and utilitarian inclination (the drive to maximize welfare for the maximum number of people).
  2. Dictator game: This task measured non-strategic generosity by having participants share money at their discretion with real community members, anonymously and without supervision. The task was designed so participants knew their decisions would affect real people using real money, but that no one involved with the experiment would review their decisions or know their choices.

We administered the dictator game two weeks before the on-site visit and again after the chills task to examine:

  • Whether the chills-augmenting intervention causes more chills
  • Whether chills augmentation leads to greater downstream self-transcendence and generosity
  • Whether getting chills causes increases in self-transcendence and generosity independently of augmentation
  • Whether getting chills mediates the intervention’s effect

While detailed analysis of these behavioral measures and their relationships is ongoing, we can report our primary findings:

  1. Those in the frisson-augmented condition showed greater aversion to harming others in moral dilemmas, and showed less maladaptive beliefs related to emotional deprivation. 
  2. Those who experienced chills behaved more generously toward high income avatars (toward whom participants are generally less generous), in other words, they were more generally egalitarian across conditions.
  3. The more chills participants experienced, the more connected they felt to others, and the more motivated they felt to help others and live in a virtuous way. 

Our task over the next several months is to qualify, situate, and disentangle the reasons for these main effects. We’ll determine who was more prone to respond to our intervention and what other downstream beliefs and states were changed that might explain increased generosity after these extraordinary experiences.

This will inform ongoing studies to better personalize interventions, as well as complex systems-based simulations to help us understand how democratizing such experiences could change society and culture.

Stay tuned!

*As described to our participants, we have calculated the amount of money shared with each LA community member, and they are being compensated as this post is being drafted.

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chills can help anhedonia

Chills Improve Reward Learning in Anhedonic Depression

E4001, Manuscript, Proceedings

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Aesthetic chills modulate reward learning in anhedonic depression

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Jain, A., Schoeller, F., Esfand, S., Duda, J., Null, K., Reggente, N., Pizzagalli, D. A., & Maes, P. (2024). Aesthetic chills modulate reward learning in Anhedonic depression. Journal of Affective Disorders, 370, 9–17. https://doi.org/10.1016/j.jad.2024.10.038

Jain, Abhinandan, et al. “Aesthetic chills modulate reward learning in Anhedonic depression.” Journal of Affective Disorders, vol. 370, Oct. 2024, pp. 9–17, doi:10.1016/j.jad.2024.10.038.

@article{Jain_Schoeller_Esfand_Duda_Null_Reggente_Pizzagalli_Maes_2024, title={Aesthetic chills modulate reward learning in Anhedonic depression}, volume={370}, url={https://doi.org/10.1016/j.jad.2024.10.038}, DOI={10.1016/j.jad.2024.10.038}, journal={Journal of Affective Disorders}, author={Jain, Abhinandan and Schoeller, Felix and Esfand, Shiba and Duda, Jessica and Null, Kaylee and Reggente, Nicco and Pizzagalli, Diego A and Maes, Pattie}, year={2024}, month=oct, pages={9–17} }

Working with Abhi Jain at MIT Media Lab and Diego Pizzagalli’s team at McLean Hospital, we recently investigated whether aesthetic chills could improve reward learning in individuals with anhedonic depression– an important follow-up on our work showing how chills can update depression schemas.

Anhedonia – the reduced ability to feel pleasure or motivation – affects up to 70% of depressed patients and predicts poor treatment outcomes. Current antidepressants (SSRIs) can sometimes worsen anhedonic symptoms, leaving that patient population in need for new treatment options.

Based on previous findings showing aesthetic chills engage the brain’s mesocortical reward circuit, we tested whether aesthetic chills could temporarily improve reward learning in anhedonic individuals. To measure reward learning, we used our collaborator Diego Pizzagalli’s probabilistic reward task (PRT). The PRT measures how well people modify their behavior based on rewards – participants have to identify subtle differences between stimuli (e.g., distinguishing between images with slightly different numbers of dogs vs cats), with one option being rewarded more frequently than the other. Healthy people quickly develop a bias toward the more rewarded option, while anhedonic individuals typically show no response.

In our study of 103 depressed participants, anhedonic individuals who experienced chills showed significantly improved reward learning (p = .004) compared to non-responders. This effect was specific to high anhedonia participants – we saw no significant changes in those with low anhedonia or controls.

this figure shows how aesthetic chills increase reward bias in individuals with depression and anhedonia


The study used validated stimuli from ChillsDB, developed in our earlier work.

Our team is now working with ketamine clinics to implement aesthetic chills induction alongside ketamine therapy for treatment-resistant depression. The rationale is compelling: ketamine rapidly enhances neuroplasticity and dopaminergic function, while aesthetic chills naturally engage reward circuitry in a targeted way depending on the content used (speech, poetry, stories, films). By combining these approaches, we hope to amplify therapeutic effects and potentially extend ketamine’s antidepressant benefits.

We’re particularly interested in how chills might enhance the psychedelic-like experiences many patients report during ketamine sessions. Early observations suggest that carefully selected aesthetic stimuli could help guide these experiences in therapeutically meaningful directions. If you’re a clinician working with ketamine or a researcher interested in this approach, we’re looking to expand our clinical partnerships. We’re particularly interested in sites that can implement rigorous protocols and already collect standardized data. If you’re interested in collaborating or learning more, please reach out: felix@advancedconsciousness.org. 

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Aesthetic Chills and Self-Transcendence: Another step toward the democratization of mystical experience

E4001, Manuscript, Proceedings

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Christov-Moore, L., Schoeller, F., Lynch, C., Sacchet, M., & Reggente, N. (2024). Self-transcendence accompanies aesthetic chills. PLOS Mental Health, 1(5), e0000125. https://doi.org/10.1371/journal.pmen.0000125

Christov-Moore, Leonardo, et al. “Self-transcendence accompanies aesthetic chills.” PLOS Mental Health, vol. 1, no. 5, Oct. 2024, p. e0000125. https://doi.org/10.1371/journal.pmen.0000125.

@article{Christov-Moore_Schoeller_Lynch_Sacchet_Reggente_2024, title={Self-transcendence accompanies aesthetic chills}, volume={1}, url={https://doi.org/10.1371/journal.pmen.0000125}, DOI={10.1371/journal.pmen.0000125}, number={5}, journal={PLOS Mental Health}, author={Christov-Moore, Leonardo and Schoeller, Felix and Lynch, Caitlin and Sacchet, Matthew and Reggente, Nicco}, year={2024}, month=oct, pages={e0000125}, language={en} }


Some of the smallest things are the most important. These small, important things and events can escape our notice and study for a long time. They are special precisely because they are small and, paradoxically, everywhere. An incredibly important and heretofore unknown component of the human circulatory system went unnoticed until just the last decade, despite thousands of years of studying human anatomy, because it was wispy, small, and everywhere. Such is the case with the aesthetic chills phenomenon, which few people even think to name or pay attention to, yet which all of us experience. In our search to democratize non-ordinary, mystical, transformative experiences, it may prove to be a key ally—a living biological demonstration of the fact that aesthetics began not in commerce, but in religion and our encounter with the transcendent.

Over the last year, our lab has found that aesthetic chills can not only be reliably evoked, but they also show many of the classical properties of transformative psychedelic experiences. They seem to alleviate depressive symptoms, maybe even reverse maladaptive, deep-seated beliefs, and seem deeply tied to our deepest beliefs and insights. In this study, we sought to examine whether the experience of aesthetic chills could, in fact, bear the characteristics of a tiny, self-transcendent, mystical experience.

To investigate this, we exposed 3,000 people from all over California to a series of songs, videos, and speeches that previous studies had found to consistently cause chills in a majority of people examined. We had them fill out questionnaires that examined their demographic qualities, personality traits, proneness to religious experiences and thinking, and even their political orientation. Then we showed them the video or song and had them fill out another series of questionnaires, assessing their mood, asking them whether they got chills and how intense they were, and importantly, asking if they experienced any of the classical three components of a crucial state known as self-transcendence.

A brief aside on what self-transcendence is: first coined in the 1980s within nursing literature, it was a trait used to describe a state or proclivity that seemed to correlate with and predict long-term health and well-being among people approaching old age. The state was characterized by:

1. Feelings of becoming one with everything, of ego dissolving

2. Feeling connected to one’s deeper self, to the world, and to other people

3. A sense of moral elevation, a motivation to live a nobler or more virtuous life, and a sense of compassion towards others

As it turns out, self-transcendence predicts well-being, resilience to adverse events, and prosocial, empathetic behavior in people of all ages, nationalities, creeds, and orientations. Importantly, having a self-transcendent event—whether it be a major life event, a psychedelic experience, an advanced meditative state, or immersion in nature—has been shown to cause greater well-being, greater resilience, and a greater inclination to help others.

What we found and replicated in independent samples in both California and Texas, as well as in yet another recent replication (in total, some 5,000 people), was an incredibly significant and robust relationship between the experience of chills, its intensity, and self-transcendence. Over and over again, with remarkable consistency, if a person experiences chills and to the extent to which they experience them, they will also report feeling that their ego is dissolved, that they are connected to the world and their deeper selves, and that they feel motivated to live in a kinder, nobler, more virtuous way.

In fact, adding chill-inducing music to a guided meditation increases people’s perception of its self-transcendent qualities and enhances the impact and sense of immersion people report from the meditation. What these findings reveal is that this small but ubiquitous human experience may be a microcosm of the transformative, mystical experiences often considered to be elusive or difficult to achieve for most of the population.

The more we can harness these little experiences and combine them, the more we may be able to bring these central meaning-making experiences—once thought to be the sole domain of psychedelics, religion, or advanced meditation—to that vast mass of people who, in our modern era, are perhaps too skeptical for religion and averse to the psychedelic experience. This could help improve their lives, improve their behavior towards others, and sustain a sense of meaning otherwise all too often taken up by consumerism or demagogues.

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empathy pain touch dissimilarity

Empathy from Dissimilarity In Neural Responses To Touch and Pain

E4001, Manuscript, Proceedings, PSAI

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Lulla, R., Christov-Moore, L., Vaccaro, A., Reggente, N., Iacoboni, M., & Kaplan, J. (2024). Empathy from Dissimilarity: Multivariate Pattern Analysis of Neural Activity During Observation of Somatosensory Experience. Imaging Neuroscience. https://doi.org/10.1162/imag_a_00110

Lulla, Rishi, et al. “Empathy from Dissimilarity: Multivariate Pattern Analysis of Neural Activity During Observation of Somatosensory Experience.” Imaging Neuroscience, Jan. 2024, doi:10.1162/imag_a_00110.

@article{Lulla_Christov-Moore_Vaccaro_Reggente_Iacoboni_Kaplan_2024, title={Empathy from Dissimilarity: Multivariate Pattern Analysis of Neural Activity During Observation of Somatosensory Experience}, url={https://doi.org/10.1162/imag_a_00110}, DOI={10.1162/imag_a_00110}, journal={Imaging Neuroscience}, author={Lulla, Rishi and Christov-Moore, Leonardo and Vaccaro, A. and Reggente, Nicco and Iacoboni, Marco and Kaplan, Jonas}, year={2024}, month=jan }

Empathy: A Deeper Look

Empathy involves both understanding and sharing in the states of others. It’s been relatively established that empathy is related to our ability to simulate and internalize another’s experience as if it is happening to us, referred to as the ‘simulationist’ theory of empathy. However, how these simulations translate into empathic ability remains unclear. In an article titled ‘Empathy from Dissimilarity: Multivariate Pattern Analysis of Neural Activity during Observation of Others’ Somatosensory States’, researchers from the University of Southern California and the Institute for Advanced Consciousness Studies investigate the relationship between internal simulations and empathic traits. They question whether the importance of these simulations depends on not only the strength of the simulation but more so the distinguishability across simulated states.

Brain Patterns and Simulation

To evaluate this theory using patterns of neural activity, researchers recruited 70 healthy participants to undergo MRI imaging while observing videos intended to simulate certain sensory states. The videos consisted of a hand experiencing painful and tactile stimulation and a hand in isolation as control. They used advanced multivariate analysis techniques to delve into the granularity of neural activity, such as differences in neural patterns when simulating pain versus touch. This allowed them to probe whether the key to the simulationist theory lay within the relationship between differences in neural patterns of simulated states and empathic ability.

Dissimilarity as a Key Factor

This article evaluates empathy through the lens of ‘pattern dissimilarity’ rather than overall activation during observed experiences of others, analyzing areas of the brain in which pattern dissimilarity was predictive of empathic traits. This proved to be more useful than traditional methods of evaluating neural responses that rely on average activation levels rather than activity patterns. Researchers discovered that pattern dissimilarity was predictive of empathic traits in the same areas of the brain that would be engaged if the participant was experiencing the observed stimulation themselves. This sheds light on the intricacies of somatosensation, our bodily perception of the senses, that contribute to empathic ability.

Implications for Understanding Empathy

These findings show how pattern dissimilarity may provide deeper information than traditional analysis methods when researching cognitive functions such as empathy. Researchers suggest that the distinguishability of simulated internal states in somatosensory areas of the brain is predictive of an individual’s sympathetic reactions to the distress of others. Perhaps it’s not only the level of brain activity during internal simulation, but more so the uniqueness and distinguishability of that brain activity that leads us to feel for and understand others.

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neural correlates of chills as shown by a frozen brain

The neural correlates of chills: How bodily sensations shape emotional experiences

E4001, Manuscript, Proceedings

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Schoeller, F., Jain, A., Pizzagalli, D. A., & Reggente, N. (2024). The neurobiology of aesthetic chills: How bodily sensations shape emotional experiences. Cognitive, Affective, & Behavioral Neuroscience. https://doi.org/10.3758/s13415-024-01168-x

Schoeller, Félix, Abhinandan Jain, et al. “The neurobiology of aesthetic chills: How bodily sensations shape emotional experiences.” Cognitive, Affective, & Behavioral Neuroscience, Feb. 2024, doi:10.3758/s13415-024-01168-x.

@article{Schoeller_Jain_Pizzagalli_Reggente_2024, title={The neurobiology of aesthetic chills: How bodily sensations shape emotional experiences}, url={https://doi.org/10.3758/s13415-024-01168-x}, DOI={10.3758/s13415-024-01168-x}, journal={Cognitive, Affective, & Behavioral Neuroscience}, author={Schoeller, Félix and Jain, Abhinandan and Pizzagalli, Diego A. and Reggente, Nicco}, year={2024}, month=feb }

Neural Correlates of Chills: How the Brain Creates a Powerful Emotional Response

Aesthetic chills are a universal emotional response characterized by shivers and goosebumps in reaction to specific rewarding or threatening stimuli, such as music, films, or speech. What makes this phenomenon so intriguing is that it simultaneously involves subjective feelings and measurable physical sensations, providing a tangible link between the mind and body.

The Role of Brain Regions and Networks

Recent research has shed light on the specific brain regions and networks involved in the experience of aesthetic chills. Understanding the neural correlates of chills helps us delve into fascinating questions about the mind-body connection.

Our review highlights key questions that aesthetic chills can help us answer: How precisely do bodily sensations influence emotional experiences? What is the role of prediction and uncertainty in shaping our feelings? And how does the brain balance processing rewards versus threats?

neural correlates of chills are vast and span the cerebrum, cerebellum, and brainstem

The Mesocorticolimbic System: A Key Player in Chills

By synthesizing evidence from neuroimaging studies, we propose that aesthetic chills engage a distinct brain network involving the mesocorticolimbic system. This network includes regions like the ventral tegmental area (VTA), nucleus accumbens (NAcc), amygdala (AMG), and frontal areas such as the orbitofrontal cortex (OFC) and ventromedial prefrontal cortex (vmPFC). Crucially, the VTA releases dopamine, a neurotransmitter critical for reward processing and motivation, throughout these regions.

Chills, Reward, Learning, and the Brain’s Predictions

neural correlates of chills seem to depend on the learning rate

We suggest that aesthetic chills may correspond to peaks in consummatory pleasure, marking the transition from the “wanting” phase of reward to the “liking” and “learning” phases. This perspective aligns with the observation that chills often occur during the culmination of an aesthetic experience, such as the resolution of a narrative or musical tension.

neural correlates of chills seem associated with the anticipation and reward response.

Interoception and the Insula

The involvement of the insula, a region linked to interoception (the perception of internal bodily states), highlights the importance of peripheral signals in shaping the emotional quality of chills. This is further supported by findings that manipulating bodily sensations, such as enhancing the feeling of cold, can intensify the experience of chills and its downstream effects on cognition.

Individual Differences and the Experience of Chills

Interestingly, our susceptibility to aesthetic chills seems to be influenced by individual differences in personality traits like openness to experience and absorption, as well as biological factors such as gene variants affecting neurotransmitter function. This suggests that our propensity for chills is shaped by a complex interplay of psychological and neurobiological factors.

Dopamine, Prediction Errors, and Learning

We propose that the neurotransmitter dopamine plays a key role in aesthetic chills by encoding the precision of our brain’s predictions. When an aesthetic stimulus violates our expectations in a way that is ultimately rewarding, dopamine release signals the need to update our predictions, enhancing memory consolidation and learning. This process may underlie the heightened attention and memory effects observed during chills.

Mental Health Implications

Understanding the neurobiology of aesthetic chills has important implications for mental health. Dysfunctional precision encoding of prediction errors by dopamine is implicated in conditions like schizophrenia, depression, and addiction. Preliminary evidence suggests that experiencing aesthetic chills may help mitigate anhedonia (loss of pleasure) in depression by improving reward learning and shifting maladaptive self-beliefs. The therapeutic potential of chills lies in their ability to promote positive emotional states and cognitive flexibility.

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Predicting Chills – Characterizing Individual Differences in Peak Emotional Response

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Schoeller, F., Christov-Moore, L., Lynch, C., Diot, T., & Reggente, N. (2024). Predicting Individual Differences in Peak Emotional Response. PNAS Nexus, 3(3). https://doi.org/10.1093/pnasnexus/pgae066

Schoeller, Félix, Leonardo Christov-Moore, et al. “Predicting Individual Differences in Peak Emotional Response.” PNAS Nexus, vol. 3, no. 3, Feb. 2024, https://doi.org/10.1093/pnasnexus/pgae066.

@article{Schoeller_Christov-Moore_Lynch_Diot_Reggente_2024, title={Predicting Individual Differences in Peak Emotional Response}, volume={3}, url={https://doi.org/10.1093/pnasnexus/pgae066}, DOI={10.1093/pnasnexus/pgae066}, number={3}, journal={PNAS Nexus}, author={Schoeller, Félix and Christov-Moore, Leonardo and Lynch, Caitlin and Diot, Thomas and Reggente, Nicco}, year={2024}, month=feb }

Predicting Chills: Unraveling the Factors Behind a Powerful Emotional Response

Have you ever felt a shiver run down your spine when deeply moved by a piece of music or a scene in a film? Those “aesthetic chills” offer a fascinating glimpse into the interplay of our emotions and our individual experiences. In a recent study published in PNAS Nexus, we aimed to understand what makes some people more likely to feel these chills.

The Study Design

Our approach was multifaceted:

  • Stimuli Selection: We used innovative data mining techniques on social media platforms to curate a database of stimuli with a proven track record of inducing chills.
  • Diverse Participants: We exposed a diverse group of over 2,900 participants from Southern California to these stimuli. Data on their demographics, personality traits, and emotional responses were carefully collected.

Key Findings: Who’s Most Likely to Experience Chills

Our results were illuminating:

  • Demographics: Certain demographic factors, such as being middle-aged, highly educated, and male, were associated with a greater likelihood of experiencing chills.
  • Personality’s Impact: We also identified specific personality traits, like extraversion and conscientiousness, that were linked to more intense chills responses.
  • Microcultures and Resonance: Perhaps the most intriguing finding was the use of latent class analysis to uncover hidden “microcultures.” These subgroups, characterized by specific combinations of demographic and psychological attributes, were significantly more likely to experience chills. This points to the role of cultural resonance in shaping these emotional experiences.
predicting chills is hard - this image shows a bunch of people in a where's waldo style backdrop all looking at different pieces of content

Predictive Power: Can We Foresee Chills?

We pushed the analysis further by employing machine learning algorithms to see if we could predict the occurrence and intensity of chills based on a combination of personal characteristics. Our models achieved up to 73.5% accuracy in predicting whether someone would experience chills and accounted for 48% of the variance in chills intensity.

The Significance of Our Work

This study has far-reaching implications. By identifying the key factors that shape our susceptibility to aesthetic chills, we open doors to more targeted and personalized approaches to studying these experiences in a laboratory setting. Furthermore, understanding these “chills profiles” could pave the way for using music, art, or other stimuli in therapeutic contexts – perhaps helping reduce symptoms like anhedonia in depression.

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individual differences in aesthetic chills

Individual Differences in Aesthetic Chills

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Schoeller, F., Moore, L., Lynch, C., & Reggente, N. (2023c). ChillsDB 2.0: Individual Differences in aesthetic chills among 2,900+ Southern California participants. Scientific Data, 10(1). https://doi.org/10.1038/s41597-023-02816-6

Schoeller, Felix, et al. “ChillsDB 2.0: Individual Differences in Aesthetic Chills Among 2,900+ Southern California Participants.” Scientific data 10.1 (2023): 922.

@article{schoeller2023chillsdb, title={ChillsDB 2.0: Individual Differences in Aesthetic Chills Among 2,900+ Southern California Participants}, author={Schoeller, Felix and Christov Moore, Leo and Lynch, Caite and Reggente, Nicco}, journal={Scientific data}, volume={10}, number={1}, pages={922}, year={2023}, publisher={Nature Publishing Group UK London} }

Understanding Individual Differences in Aesthetic Chills

At IACS, we have been deeply engaged in the scientific exploration of aesthetic chills – those spine-tingling, goosebump-inducing responses evoked by stimuli such as music, films, and stories at large. These responses are recognized as a universal indicator of peak human experiences that transcend cultural boundaries.

Tools for Investigating Aesthetic Chills

One of our main goals is to build an open-source technological infrastructure for researchers to study chills in the lab. Our first output was ChillsDB, a database of audiovisual stimuli designed and validated to reliably induce aesthetic chills in a laboratory setting. This tool represented a breakthrough for the field, enabling researchers to investigate the psychological and neurological foundations of this intense emotional response under controlled conditions.

individual differences in aesthetic chills - this image shows a person viewing different pieces of content to emphasize how different people get chills from different content.

ChillsDB 2.0: Focusing on Individuality

We are now excited to announce the release of ChillsDB 2.0, published in Nature: Scientific Data, which marks a significant expansion of our initial efforts. In this updated version, we have enriched our dataset with inputs from nearly 3,000 diverse participants from Southern California. This enhancement not only includes responses to a selection of stimuli from our original database and new additions but also encompasses comprehensive data on participants’ demographics, personality traits, and emotional states before and after exposure to each stimulus.

The Therapeutic Potential of Aesthetic Chills

ChillsDB 2.0 has already proven to be a foundational resource for examining the therapeutic possibilities of aesthetic chills in treating conditions like depression. By elucidating the mechanisms behind these peak emotional states, we aim to discover novel methods for enhancing mood and introducing new perspectives to both clinical and general populations.

The Path Forward

While significant efforts are still required to comprehensively understand the phenomenology and neurobiology of aesthetic chills and to harness these insights for improving well-being, this new database represents an important step forward.

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Aesthetic chills mitigate maladaptive cognition in depression-- an important finding showcasing the power of positive affect promotion.

Aesthetic chills mitigate maladaptive cognition in depression

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Schoeller, F., Jain, A., Adrien, V., Maes, P., & Reggente, N. (2024). Aesthetic chills mitigate maladaptive cognition in depression. BMC Psychiatry, 24(1). https://doi.org/10.1186/s12888-023-05476-3

“Aesthetic Chills Mitigate Maladaptive Cognition in Depression.” BMC Psychiatry, vol. 24, no. 1, Jan. 2024, https://doi.org/10.1186/s12888-023-05476-3.

@article{Schoeller_Jain_Adrien_Maes_Reggente_2024c, title={Aesthetic chills mitigate maladaptive cognition in depression}, volume={24}, url={https://doi.org/10.1186/s12888-023-05476-3}, DOI={10.1186/s12888-023-05476-3}, number={1}, journal={BMC Psychiatry}, author={Schoeller, Félix and Jain, Abhinandan and Adrien, Vladimir and Maes, Pattie and Reggente, Nicco}, year={2024}, month=jan }

Using peak positive affect (aesthetic chills) to help with depression

In our recent collaboration with Pattie Maes’s Fluid Interfaces group at MIT Media Lab and Dr. Vladimir Adrien from Assistance Publique Hôpitaux de Paris (APHP) in France, we investigated the potential for aesthetic chills to serve as an innovative intervention for major depressive disorder. This effort is a considerable advancement towards the notion of promoting positive affect in depression, which stands in contrast to standard care which is mostly focused on mitigating negative affect.

Instead of focusing on how to help individuals with depression not feel so bad, this work suggests the potential of helping those individuals by presenting them with content so they can feel good.

Aesthetic chills are characterized by sensations like shivers, goosebumps, and tingling that arise in response to emotional experiences with art, music, or nature. We hypothesized that by eliciting chills through validated multimedia stimuli, we could positively influence the core beliefs and self-schemas of individuals with depression. Across two studies with 96 participants diagnosed with major depressive disorder, we engaged participants in randomized sessions involving chill-inducing and neutral control stimuli across visual, auditory, and written modalities. Our results demonstrated that aesthetic chills induced a notable increase in self-acceptance among depressed participants. Chill-inducing stimuli appeared to facilitate positive emotional breakthroughs and shifts in self-perception that could address cognitive distortions related to depression. The data further suggest that aesthetic chills may engage reward-related neural pathways similarly to interventions like psychedelic-assisted therapy.

Individuals with major depressive disorder reported more emotional breakthroughs in their maladaptive cognition (e.g., lack of self-acceptance) when they reported getting chills compared to individuals who viewed the same content, but didn’t get chills. This also scaled as a function of the intensity of those chills.

While preliminary, these findings bring much-needed attention to the potential for aesthetic chills to positively influence core beliefs and schemas related to the self and one’s place in the world. For individuals with depression stemming from early adverse experiences, chill-inducing stimuli could foster emotional catharsis and lasting change to maladaptive self-narratives developed as coping mechanisms. Our research provides initial evidence that the biological processes involved in aesthetic chills can be harnessed for therapeutic ends. Chill-based interventions offer a promising avenue for large-scale study given the ease of dissemination through multimedia experiences.

Looking forward, further research should explore the neurophysiological mechanisms of aesthetic chills and biomarkers that may predict individual responses. Larger clinical trials are needed to investigate optimal protocols and delivery methods for chill-based therapy. We believe aesthetic chills represent an innovative non-pharmacological intervention that warrants greater attention from the psychiatry, psychology, and human-computer interaction communities.

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